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Sulfonamide residues in eggs.

A Romváry1, F Simon

  • 1Department of Pharmacology, University of Veterinary Science, Budapest, Hungary.

Acta Veterinaria Hungarica
|January 1, 1992
PubMed
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Sulfonamide residues are detectable in eggs within one day of medication in laying hens. Complete elimination requires 5.2-7.4 days, underscoring the importance of the 10-day withdrawal period for food safety.

Area of Science:

  • Veterinary Pharmacology
  • Food Safety
  • Animal Science

Background:

  • Sulfonamides are commonly used in poultry for disease treatment.
  • Understanding drug residue persistence in eggs is crucial for consumer safety.
  • Laying hens' medication via drinking water necessitates residue analysis in edible products.

Purpose of the Study:

  • To quantify sulfonamide residues in eggs from laying hens treated with sulfaquinoxaline or a sulfonamide mixture.
  • To determine the absorption and elimination kinetics of sulfonamides in egg white and yolk.
  • To evaluate the adequacy of the current 10-day withdrawal period for sulfonamides in poultry.

Main Methods:

  • Two experimental trials involving laying hens treated with sulfonamides via drinking water.

Related Experiment Videos

  • Spectrophotometric analysis of sulfonamide residues in eggs collected during and after treatment.
  • Pharmacokinetic analysis to determine absorption half-life and peak drug levels in egg components.

    • Main Results:

    • Sulfonamide residues were detected in eggs laid after the first day of treatment.
    • Absorption half-lives were 0.4-0.6 days (egg white) and 0.93-1.08 days (egg yolk).
    • Complete sulfonamide elimination requires an estimated 5.2-7.4 days, with residues persisting in yolk for up to 3 days post-treatment.

    Conclusions:

    • The 10-day withdrawal period for sulfonamides in laying hens is essential to prevent violative residue levels in eggs.
    • Sulfonamide absorption and elimination kinetics vary between egg white and yolk.
    • Further research may be needed to optimize withdrawal times based on specific sulfonamide formulations and dosages.