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Updated: Aug 29, 2026
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
[Detection of hepatitis E virus on a blood donor and its infectivity to rhesus monkey]
Ning-shao Xia1, Jun Zhang, Ying-jie Zheng
1The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen University, Xiamen 361005, China.
Objective:
To understand the infectivity and pathogenicity of the plasma of hepatitis E virus (HEV) viremia to primate animals.
Methods:
RNA fragment of HEV genotype IV was detected on one healthy donor who was positive for anti-HEV IgM and negative for anti-HEV IgG. Then 10 ml plasma from above donor was transfused to rhesus monkey to observe its infectivity and pathogenicity.
Results:
Acute hepatitis E was developed in rhesus monkey who accept HEV RNA positive plasma. It was confirmed by virological, immunological, biochemical and histopathological data.
Conclusion:
Acute hepatitis E can be induced by plasma transfusion of HEV viremia, which indicate the possibility of transfusion transmitted hepatitis E
