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[Evaluation of the reliability of three different hepatitis E diagnosis reagents on the clinical acute hepatitis E]
Ying-jie Zheng1, Qing-wu Jiang, Jun Zhang
1The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen University, Xiamen 361005, China.
Objective:
To evaluate the reliability of different hepatitis E diagnosis reagent tests on the acute hepatitis E.
Methods:
Three acute hepatitis E diagnosis tests, E2-IgM (Wantai, China), GL-IgM and GL-IgG (Genelabs, Singapore) were compared for their reliability in a sera panel composed by 273 healthy individuals and 525 hepatitis.
Results:
The specificity of E2-IgM on the diagnosis of acute hepatitis E was 100.0%, it was significantly higher than GL-IgM (96.7%) and GL-IgG (85.4%). The sensitivity of E2-IgM and GL-IgG were 97.9% and 93.8% respectively, both significantly higher than GL-IgM (72.9%). Among 65 acute hepatitis cases being positive on GL-IgM test but negative on E2-IgM, 58 (89.2%) cases were found to be positive with anti-hepatitis A virus IgM, it indicated that the GL-IgM test might be interfered by other IgM antibodies on serum.
Conclusion:
E2-IgM is a good test for the diagnosis of acute hepatitis E.
