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Construction of recombinant adenoviruses that produce infectious hepatitis B virus

Martin Sprinzl1, Jérôme Dumortier, Ulrike Protzer

  • 1Department of Internal Medicine I, University of Mainz, Germany.

Methods in Molecular Medicine
|February 6, 2004
PubMed
Abstract

No abstract available in PubMed .

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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...