Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quinacrine sterilization: a retrospective.

J Zipper1, E Kessel

  • 1Department of Obstetrics and Gynecology, Sótero del Río Hospital, University of Chile, Santiago, Chile. dzipper@entelchile.net

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|February 7, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

25 years of quinacrine sterilization experience in Chile: review of 2,592 cases.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2018
Same author

Quinacrine sterilization: a retrospective.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2018
Same author

Properties of AtT-20 cells in serum-reduced medium.

In vitro cellular & developmental biology. Animal·2016
Same author

25 years of quinacrine sterilization experience in Chile: review of 2,592 cases.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2004
Same author

Study of the conformational transition of A beta(1-42) using D-amino acid replacement analogues.

Biochemistry·2001
Same author

Pregnancy rates among Chilean women who had non-surgical sterilization with quinacrine pellets between 1977 and 1989.

Contraception·2000
Same journal

Brugada syndrome in pregnancy.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
Same journal

Letter to the editor: A comparison in maternal and neonatal outcomes between mild fundal pressure and vacuum extraction for shortening the second stage of labor-Fundal pressure maneuvers are not created equal.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
Same journal

Maternal serum thrombospondin-4 levels in placenta accreta spectrum: A case-control study.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
Same journal

Response: A comparison in maternal and neonatal outcomes between mild fundal pressure and vacuum extraction for shortening the second stage of labor-Reconsidering the use of the term "mild fundal pressure" in obstetric practice.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
Same journal

Comparing functionality, anxiety and depression during pregnancy and postpartum in women with hypertensive disorders: Findings from the WOICE assessment.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
Same journal

Response: A comparison in maternal and neonatal outcomes between mild fundal pressure and vacuum extraction for shortening the second stage of labor-Fundal pressure maneuvers are not created equal.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
See all related articles

Quinacrine sterilization (QS) offers a safe, effective, and inexpensive non-surgical female sterilization method. Developed to overcome initial absorption issues, the pellet form is now widely used with over 98% protection at two years.

Area of Science:

  • Reproductive health
  • Gynecology
  • Pharmacology

Background:

  • High rates of septic abortion in high-parity women necessitated safer sterilization.
  • Early quinacrine sterilization trials faced challenges with drug absorption and side effects.

Purpose of the Study:

  • To trace the development of quinacrine sterilization (QS).
  • To evaluate the safety and efficacy of a modified quinacrine sterilization method.

Main Methods:

  • Review of published reports on quinacrine sterilization development.
  • Clinical trials involving transcervical instillation of quinacrine formulations.
  • Development and testing of a slow-dissolving quinacrine pellet system.

Main Results:

Related Experiment Videos

  • Initial quinacrine slurry method showed efficacy but had significant side effects and absorption issues.
  • The revised pellet form, delivered transcervically, demonstrated improved safety and efficacy.
  • The standard protocol using seven 36 mg pellets, administered twice a month apart, achieved over 98% protection at 2 years.

Conclusions:

  • Quinacrine sterilization (QS) is ready for widespread adoption.
  • QS is particularly suitable for women in resource-limited settings or those who are poor surgical candidates.
  • QS provides a viable alternative for women with contraindications or fear of surgical sterilization.