Comparison of static airway pressures during total liquid ventilation while applying different expiratory modes and...

To compare pump driven (active) and gravity-siphon (passive) expiration modes during perfluorocarbon total liquid ventilation (TLV), a liquid ventilator was developed capable of providing either expiration mode. In a prospective, controlled laboratory study, 90 rabbits (3.2 +/- 0.1 kg) were anesthetized, tracheotomized, killed. After prefill with 12 ml/kg perflubron and TLV for 90 minutes (tidal volume 12 ml/kg, I:E ratio 1:2), randomly using passive (height 40 or 80 cm) or active expiration, respiratory rates were 4, 8, or 12/min. Static peak inspiratory and end-expiratory intratracheal pressures were measured at 5 minute intervals. Peak inspiratory and end-expiratory were constant in active groups, and increases in all 40 cm and 80 cm passive groups were significant. Differences between groups were significant for expiratory mode but not for respiratory rates. Only passive groups showed significant increases in body weight after TLV. Percentage of fluorothoraces was 10% using active and 85% using passive expiration. Based upon the stability of intrapulmonary pressures and volumes and a reduced rate of fluorothoraces, active expiration is more efficient than passive drainage during TLV.