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[Dynamic change in interleukin-18 and its relationships with multiple organ dysfunction syndrome]
Jing-Qu Liu1, Zhong-Jie He, Hong-Yuan Lin
1Trauma Center, 304th Hospital of PLA, Beijing 100037, China.
Summary
Major trauma significantly elevates interleukin-18 (IL-18) levels in plasma, particularly on days 4 and 7 post-injury. Higher IL-18 concentrations correlate with increased risk of multiple organ dysfunction syndromes.
Area of Science:
- Biomedical science
- Immunology
- Trauma research
Context:
- Trauma patients exhibit complex inflammatory responses.
- Interleukin-18 (IL-18) is a pro-inflammatory cytokine implicated in various disease states.
- Understanding post-trauma cytokine dynamics is crucial for predicting patient outcomes.
Purpose:
- To quantify plasma IL-18 levels in trauma patients.
- To investigate the association between IL-18 and the development of multiple organ dysfunction syndromes (MODS).
Summary:
- Plasma IL-18 concentrations were measured in 54 trauma patients using ELISA at multiple time points (admission, day 4, 7, 14).
- Patients were stratified into low (L-ISS) and high (H-ISS) injury severity groups.
- Significantly elevated IL-18 levels were observed on post-trauma days 4 and 7, with higher concentrations in patients who developed organ dysfunction.
Impact:
- Major trauma induces a substantial increase in IL-18.
- Elevated IL-18 may serve as a potential biomarker for predicting organ dysfunction following trauma.
- This finding contributes to the understanding of trauma-induced inflammation and its systemic consequences.