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Related Experiment Videos

"Stromatogenesis" and tumor progression.

Efthimios Sivridis1, Alexandra Giatromanolaki, Michael I Koukourakis

  • 1Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece.

International Journal of Surgical Pathology
|February 7, 2004
PubMed
Summary

Stromatogenesis, the formation of new tumor stroma, aids cancer invasion and metastasis. This process involves specific stromal cells and extracellular matrix changes, potentially indicating early stromal invasion.

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Area of Science:

  • Oncology
  • Pathology
  • Cancer Biology

Background:

  • Stroma formation, termed "stromatogenesis," occurs alongside tumor growth and invasion.
  • Newly formed stroma facilitates tumor cell movement at invasion fronts and metastasis sites.
  • Stromal composition varies, being loose and edematous at advancing fronts and dense centrally.

Purpose of the Study:

  • To define "stromatogenesis" and its characteristics during tumor progression.
  • To identify key cellular and extracellular matrix (ECM) components involved in stromatogenesis.
  • To elucidate the role of stromatogenesis in facilitating tumor invasion and metastasis.

Main Methods:

  • Histological analysis of tumor tissues at various invasion and metastasis sites.
  • Immunohistochemical staining for specific cellular markers (e.g., MIB-1, alpha-smooth muscle actin, CD31).

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  • Assessment of extracellular matrix composition (e.g., collagen types, fibronectin, SPARC).

    • Main Results:

    • Stromatogenesis actively occurs at tumor invasion fronts and metastasis sites.
    • Stromal cells are spindle-shaped, proliferative (high MIB-1), alpha-smooth muscle actin positive, and express thymidine phosphorylase (TP) and SPARC.
    • The associated ECM is rich in collagen III, SPARC, and new blood vessels (CD31), but depleted of collagen I and fibronectin.
    • Stromatogenesis is associated with early stromal invasion and may indicate host complicity in tumor progression.

    Conclusions:

    • Stromatogenesis is a distinct process of new stroma formation that actively supports tumor invasion and metastasis.
    • Specific molecular signatures of stromal cells and ECM characterize stromatogenesis.
    • The mechanism remains unclear but appears to be a host-driven phenomenon facilitating tumor progression.