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Acute renal failure on immune reconstitution in an HIV-positive patient with miliary tuberculosis
Andreas W Jehle1, Nina Khanna, Jörg-Peter Sigle
1Division of Transplantation Immunology and Nephrology, University Hospitals Basel, Basel, Switzerland.
Abstract:
Immune reconstitution syndrome following HAART in human immunodeficiency virus (HIV)-infected patients is characterized by inflammatory worsening of organ functions despite improvement in HIV surrogate markers of HIV infection. We describe a patient with miliary tuberculosis and urinary shedding of acid fast bacilli who developed acute renal failure 8 weeks after initiation of antituberculosis therapy and 6 weeks after initiation of HAART. The diagnostic workup and further course of disease implicated immune reconstitution syndrome as the cause of acute renal failure.
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