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Genetically engineered antibodies: progress and prospects.

A Wright¹, S U Shin, S L Morrison

¹Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024.

Critical Reviews in Immunology

|January 1, 1992

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Genetic engineering enables novel antibody production, including chimeric and humanized forms, for improved therapies. These engineered antibodies offer new functionalities but may still pose immunogenicity challenges.

Area of Science:

Biotechnology
Immunology
Molecular Biology

Background:

Antibody engineering leverages genetic techniques for novel therapeutic applications.
The inherent domain structure of antibodies facilitates diverse modifications.

Purpose of the Study:

To explore the application of genetic engineering in producing modified antibodies.
To review advancements in antibody engineering for therapeutic potential.

Main Methods:

Utilizing genetic engineering and expression systems for antibody production.
Creating chimeric, humanized, bifunctional, and fragment antibodies (Fabs, Fvs).
Employing bacteriophage display for combinatorial antibody libraries and structural analysis.

Main Results:

Related Experiment Videos

Engineered antibodies retain or gain new properties and functionalities.
Chimeric and CDR-grafted antibodies show promise in immunotherapy.
Bacteriophage libraries offer an alternative to animal immunization for generating antigen-binding specificities.

Conclusions:

Antibody engineering offers versatile strategies for developing novel therapeutics.
Further research into immunogenicity and effector functions is crucial for designing effective therapeutic antibodies.