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Genome-wide Gene Deletions in Streptococcus sanguinis by High Throughput PCR
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IS6110-mediated deletion polymorphism in isogenic strains of Mycobacterium tuberculosis

S L Sampson1, M Richardson, P D Van Helden

  • 1Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

Journal of Clinical Microbiology
|February 10, 2004
PubMed

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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...