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Use of potentiated antibiotics in wound management

Branson W Ritchie1, Richard E Wooley, Douglas T Kemp

  • 1Departments of Small Animal Medicine and Medical Microbiology and Parasitology, University of Georgia, College of Veterinary Medicine, Athens, GA 30602, USA. britchie@vet.uga.edu

The Veterinary Clinics of North America. Exotic Animal Practice
|February 11, 2004
PubMed

Insights

Tricide, a chelating agent, enhances antimicrobial efficacy against multidrug-resistant pathogens. This reduces the need for higher antimicrobial doses, aiding wound healing and preventing resistance development.

Area of Science:

  • Wound healing
  • Antimicrobial resistance
  • Chelation therapy

Background:

  • Microbial colonization impedes wound healing.
  • Antimicrobial misuse drives multidrug-resistant organism (MDRO) evolution.
  • Chelating agents can potentiate antimicrobial activity.

Purpose of the Study:

  • To evaluate the efficacy of Tricide, a third-generation chelating agent, in combating multidrug-resistant pathogens.
  • To assess Tricide's ability to prevent antimicrobial resistance development.
  • To determine if Tricide reduces the required antimicrobial dosage.

Main Methods:

  • In vitro testing of Tricide against various multidrug-resistant pathogens.
  • Combination studies with Tricide and standard antimicrobial agents.
  • Assessment of Tricide's impact on antimicrobial resistance gene expression.

Main Results:

  • Tricide demonstrated effectiveness against numerous MDROs.
  • Co-administration with Tricide prevented resistance development in pathogens.
  • Significantly lower antimicrobial concentrations were needed when combined with Tricide.

Conclusions:

  • Tricide is a promising agent for managing infections caused by multidrug-resistant pathogens.
  • Tricide offers a strategy to overcome antimicrobial resistance and reduce drug toxicity.
  • This chelating agent supports effective wound care by enhancing antimicrobial treatments.

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