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Updated: Aug 19, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Summary: the science of genealogy by genetics
Josephine Johnston1, Mark Thomas
1The Hastings Center, 21 Malcolm Gordon Road, Garrison, New York 10524, USA. johnstonj@thehastingscenter.org
Abstract:
This summary lays out the basic science and methodology used in genetic testing that investigates historical population migrations and the ancestry of living individuals. The genetic markers used in this testing, and the distinction between Y-chromosome, mitochondrial and autosomes analysis, are explained and the shortcomings of these methodologies are explored.
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