Related Experiment Video
Updated: Jun 29, 2026
07:17
Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
Published on: August 23, 2024
HTLV-I associated gastric lymphoma
Zentralblatt Fur Pathologie
|November 1, 1992
Summary
A large gastric lymphoma was diagnosed in a woman positive for Human T-lymphotropic virus type 1 (HTLV-I). The lymphoma was identified as a CD4+ T-cell type, linked to HTLV-I infection.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Gastric lymphomas can arise from various cell types.
- Human T-lymphotropic virus type 1 (HTLV-I) is associated with certain malignancies.
Observation:
- A 42-year-old woman presented with a large gastric lymphoma.
- She was seropositive for HTLV-I.
Findings:
- Histological analysis revealed a diffuse large cell lymphoma.
- Phenotypic analysis showed CD3 and CD4 expression, indicating a helper/inducer T-cell origin.
- Southern blot confirmed T-cell receptor gene rearrangement and the presence of HTLV-I proviral DNA in tumor cells.
Implications:
- This case highlights the association between HTLV-I and gastric T-cell lymphoma.
- Understanding the viral role in lymphomagenesis is crucial for targeted therapies.
- Further research into HTLV-I-associated gastric malignancies is warranted.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
01:25Hiatal Hernia
A hiatal hernia is the abnormal protrusion of the stomach or other abdominal organs through the esophageal hiatus of the diaphragm into the thoracic cavity.Normally, the gastroesophageal junction (GEJ) lies below the diaphragm and is supported by the phrenoesophageal membrane, the diaphragmatic crura, and connective tissues. Weakening of these structures—due to aging, congenital defects like a short esophagus, or increased intra-abdominal pressure from coughing, obesity, pregnancy, or heavy...
01:26Gastritis II: Pathophysiology
The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...