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[Lesions of ventricular cardiomyocytes in experimental massive pulmonary embolism]
Abstract:
The damage of ventricular myocardial cells during acute experimental massive pulmonary embolism (MPE) was studied by light, polarization and electron microscopy on anaesthetized dogs. In cases, when MPE was followed by heart failure, the deep ir reversible damage of myofibrils took place, and the relative volume of myofibrils decreased in both ventricles. The damage of right ventricular myocardium, which works against increased postload during MPE, may be reason of right ventricular insufficiency.
Insights
Massive pulmonary embolism (MPE) causes irreversible damage to heart muscle cells, particularly in the right ventricle. This myocardial damage can lead to heart failure and right ventricular insufficiency.
Area of Science:
- Cardiovascular Pathology
- Pulmonary Medicine
- Experimental Biology
Background:
- Acute massive pulmonary embolism (MPE) poses a significant threat to cardiac function.
- Understanding the cellular mechanisms of myocardial damage in MPE is crucial for clinical management.
Purpose of the Study:
- To investigate the effects of acute experimental MPE on ventricular myocardial cells in dogs.
- To identify the cellular changes associated with MPE-induced heart failure.
Main Methods:
- Utilized light, polarization, and electron microscopy.
- Studied anaesthetized dogs subjected to experimental MPE.
Main Results:
- Observed deep, irreversible damage to myofibrils in both ventricles following MPE, especially when heart failure ensued.
- Noted a decrease in the relative volume of myofibrils in ventricular myocardium.
- Identified damage to the right ventricular myocardium, linked to increased workload (postload).
Conclusions:
- MPE leads to severe, irreversible myocardial cell damage.
- Right ventricular myocardium is particularly vulnerable due to increased afterload during MPE.
- Myocardial damage in the right ventricle is a likely cause of right ventricular insufficiency following MPE.