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Effects of Natural Cytokine Complex on the Myocardial Blood Flow in Normal and under Conditions of Increased

M S Tverskaya1, L V Gankovskaya2, V V Sukhoparova2

  • 1N. I. Pirogov Russian National Research Medical University, Ministry of the Health of the Russian Federation, Moscow, Russia. mstverskaya@mail.ru.

Bulletin of Experimental Biology and Medicine
|February 22, 2019
PubMed

Insights

A natural cytokine complex (interleukin-1, -2, -6, tumor necrosis factor, macrophage migration inhibitory factor, and growth and differentiation factor-beta) dilates myocardial vessels, enhancing coronary blood flow, even during heart overload. However, prolonged high cytokine levels may worsen blood flow disturbances.

Area of Science:

  • Cardiovascular Physiology
  • Immunology
  • Cytokine Biology

Background:

  • Cytokines play a role in regulating vascular function.
  • The impact of complex cytokine mixtures on myocardial hemodynamics requires further investigation.

Purpose of the Study:

  • To investigate the effects of a natural cytokine complex on myocardial blood flow.
  • To assess the influence of this complex under normal and acute heart overload conditions.

Main Methods:

  • Systemic administration of a natural cytokine complex (IL-1, IL-2, IL-6, TNF, MIF, GTFβ).
  • Assessment of myocardial blood flow under control conditions and during acute aortic stenosis.
  • Evaluation of vascular parameters including plethora, perivascular edema, and capillary density.

Main Results:

  • Cytokine complex administration caused moderate myocardial blood flow impairment with edema and plethora, but increased functioning vessels and coronary blood flow.
  • Under acute heart overload, cytokine administration resulted in more pronounced capillary density increase compared to overload alone.
  • Cytokines induced myocardial vessel dilatation and intensified blood flow, mitigating dyscirculatory changes.

Conclusions:

  • Increased blood cytokine levels promote myocardial vessel dilatation and enhanced blood flow, offering protection during hemodynamic stress.
  • Sustained or frequent hypercytokinemia could potentially lead to more severe myocardial blood flow disturbances.

Keywords:
cytokinesmyocardial blood flow

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