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[Structure and function of erythrocytes in lymphomas].

M I Loseva, L A Shpagina, I A Lisukov

    Gematologiia I Transfuziologiia
    |May 1, 1992
    PubMed
    Summary

    Red blood cell changes in lymphoma patients, including altered sulfhydryl groups and catalase activity, differ between lymphosarcoma and lymphogranulomatosis. Lymphosarcoma shows early red blood cell changes and increased mononuclears expressing specific antigens.

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    Kardiologiia·2020

    Area of Science:

    • Hematology
    • Oncology
    • Biochemistry

    Context:

    • Lymphoma encompasses various cancers affecting the lymphatic system, with distinct subtypes like lymphosarcoma and lymphogranulomatosis.
    • Red blood cells (RBCs) play a crucial role in oxygen transport and can be affected by systemic diseases.
    • Understanding RBC alterations provides insights into disease progression and potential diagnostic markers.

    Purpose:

    • To investigate and compare the specific changes in red blood cell parameters and related biomarkers in patients with lymphosarcoma versus lymphogranulomatosis.
    • To identify potential differences in the early versus advanced stages of these lymphoma subtypes based on RBC characteristics.

    Summary:

    • Significant alterations in RBCs, including sulfhydryl groups, histidine, lipoproteins, catalase activity, saponin resistance, and chemiluminescence kinetics, were observed in lymphoma patients.

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  • Lymphosarcoma exhibits early-stage RBC structural and functional changes, alongside an increase in peripheral blood mononuclears expressing erythroid differentiating antigens (glycophorin A and human erythroblast antigen).
  • In contrast, lymphogranulomatosis shows RBC changes primarily in later stages, associated with tumor intoxication and anemia, and lacks the specific mononuclear cell expression seen in lymphosarcoma.

    • Impact:

    • These findings highlight distinct hematological profiles associated with different lymphoma subtypes, aiding in differential diagnosis.
    • The identified RBC markers could serve as potential biomarkers for monitoring disease progression and therapeutic response in lymphoma patients.
    • This research contributes to a deeper understanding of the complex interplay between lymphoma and erythrocyte physiology.