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Angiomatosis with luminal cryoprotein deposition
P E LeBoit1, A R Solomon, D J Santa Cruz
1Department of Pathology, University of California, San Francisco 94143-0506.
Background:
Angioendotheliomatosis has recently been separated into two types. Malignant angioendotheliomatosis is a lymphoma in which the neoplastic cells accumulate in vascular lumens. Reactive angioendotheliomatosis is a proliferation of capillaries that is less well characterized.
Objective:
Our purpose was to describe the clinical and histopathologic features of three cases of reactive angiomatosis in patients with cryoproteinemia.
Methods:
Clinical and histologic data were correlated. Immunoperoxidase staining and electron microscopy were used in the histologic evaluation.
Results:
All three cases showed tufts of capillaries with luminal deposits of cryoproteins. Immunohistochemical studies showed that the cellularity of the tufts was primarily caused by a proliferation of pericytes.
Conclusion:
Cryoproteinemia can cause angiomatosis that simulates a vascular neoplasm.