Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intraepidermal IgA pustulosis.

D Wallach1

  • 1Department of Dermatology, Hôpital Saint-Louis, Paris, France.

Journal of the American Academy of Dermatology
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Intraepidermal IgA pustulosis is a distinct neutrophilic dermatosis presenting with pustules and IgA deposits. This condition often mimics Sneddon-Wilkinson disease and typically responds well to dapsone treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age-specific characteristics of neutrophilic dermatoses and neutrophilic diseases in children.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Pyoderma gangrenosum and Sweet syndrome: the prototypic neutrophilic dermatoses.

The British journal of dermatology·2015
Same author

Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it.

Cell death and differentiation·2015
Same author

Comparison of freehand-navigated and aiming device-navigated targeting of liver lesions.

The international journal of medical robotics + computer assisted surgery : MRCAS·2013
Same author

The extrinsic cell death pathway and the élan mortel.

Cell death and differentiation·2008
Same author

Caspase-8 deficiency facilitates cellular transformation in vitro.

Cell death and differentiation·2008
See all related articles

Area of Science:

  • Dermatology
  • Immunopathology

Background:

  • A rare group of 29 reported patients exhibit intraepidermal IgA, detected via direct immunofluorescence.
  • Clinically, this condition resembles subcorneal pustular dermatosis (Sneddon-Wilkinson disease).

Purpose of the Study:

  • To characterize the clinical and immunopathological features of intraepidermal IgA-associated dermatoses.
  • To propose a distinct diagnostic term for this condition.

Main Methods:

  • Review of reported cases with intraepidermal IgA.
  • Analysis of clinical presentation, pustule location, IgA deposition patterns, and autoantibody presence.

Main Results:

  • Pustules can be subcorneal or intraepidermal.
  • IgA deposits typically target intercellular epidermal substance; a subcorneal linear pattern is also noted.

Related Experiment Videos

  • Circulating IgA class antiepidermal autoantibodies may be present; six cases showed monoclonal IgA gammopathy.

    • Conclusions:

    • Intraepidermal IgA pustulosis is proposed as a distinct entity within neutrophilic dermatoses.
    • The condition often responds favorably to dapsone therapy.