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Actinic cheilitis granulomatosa.

Y Kuno1, S Sakakibara, N Mizuno

  • 1Department of Dermatology, Nagoya City University Medical School, Japan.

The Journal of Dermatology
|September 1, 1992
PubMed
Summary

A rare granulomatous lip lesion caused by ultraviolet B (UVB) photosensitivity was identified. This condition, termed actinic cheilitis granulomatosa, improved with topical glucocorticoids and sunscreen.

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Area of Science:

  • Dermatology
  • Photobiology

Background:

  • Actinic cheilitis is a common premalignant condition of the lips.
  • UVB radiation is a known factor in photodamage and skin cancer.

Observation:

  • A 31-year-old Japanese man presented with depigmented, swollen, and erythematous lips with erosions and crusts for 11 months.
  • Histopathology revealed dense dermal lymphoid-histiocytic infiltration and suprabasal clefts.
  • Patch and photopatch tests were negative.

Findings:

  • The patient exhibited a reduced minimal erythema dose (MED) to UVB radiation (295-330 nm).
  • Lesions were reproducible with monochromatic light at 310 and 320 nm, but not other tested wavelengths.
  • The condition responded to topical glucocorticoids and sunscreen application.

Implications:

  • This case describes a novel UVB-induced granulomatous reaction of the lips.
  • The findings suggest a specific wavelength sensitivity in this photosensitive condition.
  • The proposed term 'actinic cheilitis granulomatosa' aids in classifying this distinct lip disorder.

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