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Thyroid function tests in adults with Down's syndrome.

S Korsager, E M Chatham, H P Ostergaard Kristensen

    Acta Endocrinologica
    |May 1, 1978
    PubMed
    Summary

    Older adults with Down syndrome frequently show biochemical signs of hypothyroidism, even without typical symptoms. Regular thyroid screening is recommended for this population to detect thyroid dysfunction early.

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    [Thyroid diseases in Down's syndrome].

    Ugeskrift for laeger·1981

    Area of Science:

    • Endocrinology
    • Genetics
    • Geriatrics

    Background:

    • Down syndrome is associated with an increased risk of various health complications.
    • Thyroid dysfunction is a known comorbidity in individuals with Down syndrome.
    • Ageing in Down syndrome may further influence thyroid status.

    Purpose of the Study:

    • To investigate the thyroid status in patients over 40 years old with Down syndrome.
    • To determine the prevalence of hypothyroidism and related markers in this specific demographic.
    • To assess the correlation between biochemical findings and clinical signs of thyroid disease.

    Main Methods:

    • Study population: 24 patients aged over 40 with Down syndrome.
    • Biochemical assessments: Thyroid function tests (including thyroid stimulating hormone), and thyroid autoantibodies.
    • Clinical evaluation: Assessment for typical signs of hypothyroidism.

    Main Results:

    • Three patients (12.5%) exhibited biochemical evidence of hypothyroidism.
    • Eight patients (33.3%) had detectable thyroid autoantibodies.
    • Eight patients (33.3%) showed elevated serum thyroid stimulating hormone levels.
    • No patients presented with thyrotoxicosis or overt clinical signs of hypothyroidism.

    Conclusions:

    • Biochemical hypothyroidism is significantly more prevalent in older adults with Down syndrome compared to the general population.
    • Subclinical hypothyroidism may be common in this group, often without apparent clinical manifestations.
    • Routine thyroid status assessment is crucial for elderly individuals with Down syndrome to ensure timely diagnosis and management of thyroid dysfunction.

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