Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid function tests in adults with Down's syndrome.

S Korsager, E M Chatham, H P Ostergaard Kristensen

    Acta Endocrinologica
    |May 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [The effects of captopril and metoprolol on blood pressure and side effects in patients with mild to moderate hypertension].

    Ugeskrift for laeger·1989
    Same author

    Technetium Tc 99m uptake in postpartum thyrotoxicosis.

    Archives of internal medicine·1987
    Same author

    Thyroid dysfunction after delivery: incidence and clinical course.

    Acta medica Scandinavica·1987
    Same author

    [Acetylsalicylic acid and indomethacin in the treatment of idiopathic orthostatic hypotension and Shy-Drager's syndrome].

    Ugeskrift for laeger·1985
    Same author

    Dementia and central nervous system involvement in chronic lymphocytic leukaemia.

    Scandinavian journal of haematology·1982
    Same author

    [Thyroid diseases in Down's syndrome].

    Ugeskrift for laeger·1981
    Same journal

    Iodine deficiency in Ukraine.

    Acta endocrinologica·1993
    Same journal

    Plasma glucagon responses to insulin-induced hypoglycemia and arginine in spontaneous non-insulin-dependent diabetes mellitus (NIDDM) rats, Otsuka Long Evans Tokushima Fatty (OLETF) strain.

    Acta endocrinologica·1993
    Same journal

    Comparison between the human serum growth hormone-binding protein and the water-soluble growth hormone-binding site released from IM-9 lymphocytes.

    Acta endocrinologica·1993
    Same journal

    Prolactin stimulates [3H]dopamine release from dispersed rat tubero-infundibular dopaminergic neurons and dopamine decreases gonadotropin-releasing hormone release induced by calcium ionophore.

    Acta endocrinologica·1993
    Same journal

    Effects of long-term estradiol exposure on the hypothalamic neuron number.

    Acta endocrinologica·1993
    Same journal

    Aromatase activity in the mare ovary during estrous cycle. Measurement of endogenous steroids and of their in vitro inhibitory effect.

    Acta endocrinologica·1993
    See all related articles

    Older adults with Down syndrome frequently show biochemical signs of hypothyroidism, even without typical symptoms. Regular thyroid screening is recommended for this population to detect thyroid dysfunction early.

    Area of Science:

    • Endocrinology
    • Genetics
    • Geriatrics

    Background:

    • Down syndrome is associated with an increased risk of various health complications.
    • Thyroid dysfunction is a known comorbidity in individuals with Down syndrome.
    • Ageing in Down syndrome may further influence thyroid status.

    Purpose of the Study:

    • To investigate the thyroid status in patients over 40 years old with Down syndrome.
    • To determine the prevalence of hypothyroidism and related markers in this specific demographic.
    • To assess the correlation between biochemical findings and clinical signs of thyroid disease.

    Main Methods:

    • Study population: 24 patients aged over 40 with Down syndrome.
    • Biochemical assessments: Thyroid function tests (including thyroid stimulating hormone), and thyroid autoantibodies.

    Related Experiment Videos

  • Clinical evaluation: Assessment for typical signs of hypothyroidism.

    • Main Results:

    • Three patients (12.5%) exhibited biochemical evidence of hypothyroidism.
    • Eight patients (33.3%) had detectable thyroid autoantibodies.
    • Eight patients (33.3%) showed elevated serum thyroid stimulating hormone levels.
    • No patients presented with thyrotoxicosis or overt clinical signs of hypothyroidism.

    Conclusions:

    • Biochemical hypothyroidism is significantly more prevalent in older adults with Down syndrome compared to the general population.
    • Subclinical hypothyroidism may be common in this group, often without apparent clinical manifestations.
    • Routine thyroid status assessment is crucial for elderly individuals with Down syndrome to ensure timely diagnosis and management of thyroid dysfunction.