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A method for publishing genomic maps.

M E Frisse1, K Marrs, P Schoening

  • 1Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.

Proceedings. Symposium on Computer Applications in Medical Care
|January 1, 1992
PubMed
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This study introduces a novel method for creating and publishing physical human genome maps using an intelligent document interface. The system integrates genetic data and mapping algorithms, enabling versatile map production in various formats.

Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Physical human genome mapping is crucial for understanding genetic diseases and human evolution.
  • Existing methods for genome map creation and publication can be complex and fragmented.

Purpose of the Study:

  • To develop an integrated and user-friendly system for the creation, manipulation, and publication of physical human genome maps.
  • To leverage existing document production systems for enhanced accessibility and versatility in genomic data visualization.

Main Methods:

  • An "intelligent" document interface metaphor was employed, utilizing a programmable document production system.
  • The system interfaces with primary genetic data resources and external mapping algorithms.
  • A document architecture was developed to differentiate between primary data and data manipulations.

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Main Results:

  • A novel method for generating, modifying, and publishing physical human genome maps was successfully demonstrated.
  • The system architecture supports extensibility for diverse genetic and physical mapping challenges.
  • Genomic maps can be produced in multiple paper and electronic formats.

Conclusions:

  • The described approach offers a streamlined and accessible method for physical human genome map production.
  • The system's reliance on widely available document preparation tools enhances its practical applicability.
  • This method facilitates the dissemination of genomic information in accessible formats for broader research use.