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Effect of selected cytostatic drugs administration on the brain of young rabbits
1Department of Developmental Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
Abstract:
The aim of the study was to compare the effect of two selected cytostatic drugs (cyclophosphamide and vincristine) on the brain of young rabbits. The experimental models were similar to clinical administration of the examined drugs. Cyclophosphamide was given orally from the 5 to the 16th day of life and vincristine in a single intraperitoneal injection on the 8th day of life. Despite the assumed poor penetration of both drugs through the blood-brain barrier, both drugs induced changes in perivascular astrocytes. Other structural elements of the CNS exhibited lesions characteristic for the given drug: proliferation of endoplasmic membranes after cyclophosphamide administration and destruction of microtubules with proliferation of microfilaments after vincristine application.