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Lashley maze learning deficits in NZB mice.

L M Schrott1, V H Denenberg, G F Sherman

  • 1Biobehavioral Science Graduate Degree Program, University of Connecticut, Storrs 06269-4154.

Physiology & Behavior
|December 1, 1992
PubMed
Summary

New Zealand Black (NZB) mice exhibit poor performance in the Lashley III maze, even with additional training. This learning deficit is likely linked to hippocampal alterations, not autoimmune conditions.

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Area of Science:

  • Neuroscience
  • Immunology
  • Behavioral Genetics

Background:

  • Prior studies noted differential Lashley III maze learning between BXSB and NZB mice.
  • Both BXSB and NZB mice are autoimmune and develop cortical ectopias, complicating learning deficit attribution.
  • NZB mice exhibit known hippocampal morphological alterations.

Purpose of the Study:

  • To detail NZB mouse performance in the Lashley III maze.
  • To compare NZB maze performance with other mouse strains.
  • To investigate methods for improving NZB maze learning.

Main Methods:

  • Conventional Lashley III maze testing with 10 trials.
  • Extended trials and trials with additional intramaze visual cues for NZB mice.
  • Performance evaluation using learning indices and error counts.

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Main Results:

  • RF and BXSB mice demonstrated excellent Lashley III maze learning (high indices, few errors).
  • NZB mice consistently performed poorly (low indices, high errors).
  • Additional trials or cues did not significantly improve NZB performance.

Conclusions:

  • Differential Lashley III maze performance between mouse strains is not solely due to autoimmunity or cortical ectopias.
  • NZB mice's poor maze learning is likely mediated by their known hippocampal morphological alterations.
  • Hippocampal morphology is a potential factor influencing spatial learning deficits in mice.