Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microgravity and bone adaptation at the tissue level.

L Vico1, C Alexandre

  • 1Laboratoire de Biologie du Tissu Osseux, Gip Exercise, Faculté de Médecine Jacques Lisfranc, Saint-Etienne, France.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deletion of osteopontin or bone sialoprotein induces opposite bone responses to mechanical stimulation in mice.

Bone reports·2022
Same author

Chemical sex (chemsex) in a population of French university students.

Dialogues in clinical neuroscience·2022
Same author

Reference microarchitectural values measured by HR-pQCT in a Franco-Swiss cohort of young adult women.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

[Social defeat and schizophrenia: Hypotheses, arguments, mechanisms].

L'Encephale·2020
Same author

Klebsiella pneumoniae and Klebsiella oxytoca meningitis in infants. Epidemiological and clinical features.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2018
Same author

Deletion of OPN in BSP knockout mice does not correct bone hypomineralization but results in high bone turnover.

Bone·2018
Same journal

Increased Prevalence of Coronary Artery Calcification in Patients with Post-Surgical Hypoparathyroidism.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

Alendronate for 6 or 12 months following denosumab discontinuation in women with postmenopausal osteoporosis: A prospective observational study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

MULTIDIMENSIONAL SPATIAL MAPPING OF EXTRACELLULAR MATRIX: CARTILAGINOUS-OSSEOUS COMPOSITE FORMATION, TENDON INTEGRATION AND VASCULARIZATION DURING SKELETAL GROWTH AND REPAIR.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

Race-Neutral FRAX without BMD outperforms FRAX without BMD in a multiethnic cohort with Diabetes or Hypertension.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

Women's Musculoskeletal Health: Insights from the 2024 National Academies of Sciences, Engineering, and Medicine Report on Chronic Conditions.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

Complement factor H (CFH), an immune factor enhances osteoblast differentiation and correlates with bone density.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
See all related articles

Microgravity does not cause widespread bone loss. Instead, bone changes occur in specific areas based on their support function and remodeling rates, not generalized deficits.

Area of Science:

  • Space biology
  • Skeletal physiology
  • Bone adaptation

Background:

  • Human bone adaptation to microgravity is poorly understood.
  • Previous studies on bone changes in space are limited, especially regarding the whole skeleton.
  • Rat models show osteoporosis-like changes in the proximal tibia after short spaceflights.

Purpose of the Study:

  • To investigate the extent of bone deficits in the whole skeleton due to microgravity.
  • To analyze bone resorption and formation activities at the tissue level in response to spaceflight.
  • To understand how skeletal site and initial bone turnover influence microgravity adaptation.

Main Methods:

  • Analysis of bone resorption and formation in rat bones after spaceflights of varying durations (days to 3 weeks).

Related Experiment Videos

  • Examination of architectural features and bone cell activity in different skeletal locations.
  • Comparison of changes in weight-bearing vs. non-weight-bearing bones, and areas with/without muscular insertions.

    • Main Results:

    • Spaceflight induced osteoporosis-like changes in rat proximal tibias.
    • Bone resorption was not significantly altered in some weight-bearing areas after 7 days, while bone formation decreased.
    • Changes in bone cell activity were delayed in other areas, varying by skeletal site and initial turnover rate.
    • Acute bone changes diminished after 12.5 days and showed no further progression by 21 days.

    Conclusions:

    • Generalized bone deficits are not a direct consequence of microgravity.
    • Bone adaptation to microgravity is localized, influenced by the bone's support function and its inherent modeling/remodeling rates.
    • Skeletal site-specific responses, rather than uniform deficits, characterize bone adaptation to spaceflight.