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[The effect of fentanyl on myocardial function].
Anesteziologiia I Reanimatologiia
|July 1, 1992
Summary
Fentanyl stabilized myocardial function in isolated hearts without altering baseline parameters. This suggests fentanyl is a preferred drug for cardiosurgery patients due to reduced oxygen demand.
Area of Science:
- Cardiology
- Anesthesiology
- Pharmacology
Background:
- Myocardial function is critical during cardiosurgery.
- Fentanyl is commonly used in anesthesia.
Purpose of the Study:
- To evaluate the effect of fentanyl on myocardial function in isolated hearts.
- To determine if fentanyl impacts baseline cardiac parameters.
Main Methods:
- Isolated heart preparation.
- Perfusion with fentanyl at varying concentrations.
- Measurement of cardiac parameters (stroke volume, heart rate, coronary flow, etc.).
Main Results:
- Fentanyl up to 1.84.10(-7) M did not alter baseline parameters.
- Cardiac function remained stable and superior to controls.
- Reduced myocardial oxygen demand is hypothesized as the cause.
Conclusions:
- Fentanyl preserves myocardial function during perfusion.
- Fentanyl's properties make it suitable for cardiosurgical patients.
- Stabilization of myocardial function is linked to decreased oxygen requirements.