[The effect of exogenously administered ATP on the postischemic restoration of myocardial function]

The effect of ATP (24 x 10(-6) M) on the contractility of the isolated hearts has been studied. It has been shown that ATP infusions improved postischemic hemodynamics. The favourable effect of ATP was based on the retention of diastolic properties and compliance of the left ventricle. The percent of postischemic reduction in the force and rate of contractions was analogous to the results in the control group, but the hearts on ATP performed a greater volume of work and demonstrated higher functional reserve.