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Related Experiment Videos

Decreasing the cortical response to monocular deprivation need not decrease cell shrinkage in cat lateral geniculate

B Gordon1, R BreMiller

  • 1Institute of Neuroscience, University of Oregon, Eugene 97403.

Experimental Brain Research
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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Monocular deprivation (MD) causes visual cortex cell response changes and lateral geniculate nucleus (LGN) shrinkage. LGN cell shrinkage occurs independently of major changes in visual cortex cell responses to the deprived eye.

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Visual System Plasticity

Background:

  • Monocular deprivation (MD) in young animals alters visual cortex function.
  • MD leads to cell shrinkage in the lateral geniculate nucleus (LGN).
  • The relationship between LGN cell shrinkage and visual cortex response changes is unclear.

Purpose of the Study:

  • To investigate if LGN cell shrinkage following MD depends on altered visual cortex cell responses.
  • To determine the necessity of cortical response changes for LGN structural plasticity.

Main Methods:

  • Comparison of LGN cell shrinkage in three groups of MD kittens.
  • One group received lesions of norepinephrine and acetylcholine fibers to the visual cortex.
  • This lesioning procedure attenuated MD's effects on visual cortex responses.

Related Experiment Videos

Main Results:

  • LGN cell shrinkage was observed in all MD groups.
  • No significant difference in LGN cell shrinkage was found between control and lesioned groups.
  • The procedure to attenuate visual cortex response changes did not alter LGN shrinkage.

Conclusions:

  • LGN cell shrinkage following monocular deprivation does not require significant loss of visual cortex cell responses.
  • Structural changes in the LGN are not solely dependent on major functional alterations in the visual cortex.