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Updated: Aug 27, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Reflux esophagitis as a possible risk factor in the development of pharyngolaryngeal squamous cell carcinoma
Andrea Bacciu1, Giuseppe Mercante, Anna Ingegnoli
1Department of Otolaryngology, University of Parma, Italy. abacciu@hotmail.com
Aims And Background:
To determine the role of reflux esophagitis in the development of pharyngolaryngeal squamous cell carcinoma in non-smoking and non-drinking patients.
Methods:
The study population consisted of 92 consecutive non-smoking and non-drinking patients with histologically confirmed squamous cell carcinoma of the pharynx and the larynx. As a control, a group of 125 lifetime non-smoking and non-drinking cancer-free subjects was selected.
Results:
Patients with pharyngolaryngeal cancer had a higher prevalence of reflux esophagitis than the control subjects (P <0.0001).
Conclusions:
Our results confirm that reflux esophagitis in itself is associated with an increased risk of upper aerodigestive tract cancer.
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