Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Efficient large scale microwave assisted Mannich reactions using substituted acetophenones.

Fredrik Lehmann1, Ake Pilotti, Kristina Luthman

  • 1Department of Chemistry--Medicinal Chemistry, Göteborg University, Göteborg, Sweden.

Molecular Diversity
|February 12, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of melflufen in multiple myeloma with mutated or deleted TP53.

Experimental hematology & oncology·2025
Same author

A novel macrolide, EP395, with reduced antibacterial activity and an enhancing effect on respiratory epithelial barrier.

Pulmonary pharmacology & therapeutics·2025
Same author

Bioactivation of cinnamic alcohol in a reconstructed human epidermis model and evaluation of sensitizing potency of the identified metabolites.

Frontiers in toxicology·2024
Same author

Affibody-based hBCMA x CD16 dual engagers for NK cell-mediated killing of multiple myeloma cells.

New biotechnology·2023
Same author

A rapid intracellular enrichment of alkylating payload is essential for melphalan flufenamide potency and mechanism of action.

Biochemical and biophysical research communications·2023
Same author

Nature-Derived Epoxy Resin Monomers with Reduced Sensitizing Capacity─Isosorbide-Based Bis-Epoxides.

Chemical research in toxicology·2023
Same journal

Discovery of novel cinnamic acid derivatives with anti-Helicobacter pylori mechanism.

Molecular diversity·2026
Same journal

Tetrapeptide inhibitors of BACE-1 revealed by combined data-driven screening and physics-based free-energy refinement.

Molecular diversity·2026
Same journal

A cheminformatics and DFT exploration of a brominated sulfonamide with nonlinear optical response and preliminary in silico bioactivity assessment.

Molecular diversity·2026
Same journal

Triazoles as enzyme inhibitors: synthetic advances, mechanism of action, molecular docking studies and structure-activity relationships.

Molecular diversity·2026
Same journal

Synthesis of 9H-furo[2,3-f]chromenes using multicomponent reactions of euparin: investigation of biological activity.

Molecular diversity·2026
Same journal

Discovery of novel perillyl and myrtenyl nucleobase conjugates as dual anti-Alzheimer and antimicrobial agents.

Molecular diversity·2026
See all related articles

Microwave-enhanced Mannich reactions efficiently produce substituted Mannich bases. This study optimized conditions for fast, reproducible synthesis of these compounds in good yields and purity.

Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry

Background:

  • The Mannich reaction is a fundamental carbon-carbon bond-forming reaction in organic synthesis.
  • Efficient and scalable methods for producing Mannich bases are valuable for various chemical applications.

Purpose of the Study:

  • To develop a fast and reproducible method for synthesizing substituted Mannich bases using microwave irradiation.
  • To optimize reaction conditions for microwave-enhanced Mannich reactions.

Main Methods:

  • Microwave-assisted synthesis utilizing substituted acetophenones, paraformaldehyde, and symmetrical dialkylamines.
  • Systematic study of reaction parameters including solvent, temperature, and time.
  • Scale-up studies from small (2 mmol) to large (40 mmol) reaction scales.

Related Experiment Videos

Main Results:

  • Successful synthesis of a series of substituted Mannich bases.
  • Reactions proceeded rapidly under optimized microwave conditions.
  • Products were obtained in moderate to high yields and high purity.
  • Method demonstrated scalability from 2 mmol to 40 mmol.

Conclusions:

  • Microwave-enhanced Mannich reactions offer an efficient and rapid route to substituted Mannich bases.
  • Optimized conditions ensure reproducibility and high yields, suitable for both small and large-scale synthesis.
  • This method provides a valuable tool for accessing diverse Mannich base structures.