Synthesis of 9H-furo[2,3-f]chromenes using multicomponent reactions of euparin: investigation of biological activity

A one pot reaction was carried out in aqueous media at room temperature for the preparation of 9 H-furo[2,3-f]chromenes in high yields employing multicomponent reactins of euparin, aldehydes and 1,3-dicarbonyl compounds in the presence of Fe₃O₄/ZnO MNPs (0.02 g) as reusable nanocatalyst which was prepared via water extract od rhizhome of petasits hybridus in high yields. In another subject in this research was determining the antioxidant capacity of synthesized compounds via two methods: the diphenyl-picrylhydrazine (DPPH) radical scavenging assays and Fe³⁺ reducing. The compounds 4b and 4i exhibited a noteworthy degree of efficiency when it was compared to two compounds, namely BHT and TBHQ, among the 9 H-furo[2,3-f]chromenes compounds that were studied, namely compounds 4a-4d and 4g-4j. A further evaluation of the antibacterial activity of the compounds that were generated was carried out in a methodical manner by making use of the disk diffusion technique. Using this approach, tests were conducted against two distinct strains of Gram-negative bacteria as well as Gram-positive bacteria. The approach of synthesis that was applied for the development of 9 H-furo[2,3-f]chromenes was marked by a confluence of good properties. One of these characteristics was the ability to recover the catalyst from the reaction environment with relative ease. Other characteristics included faster reaction kinetics and greater product yields.