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Updated: Dec 30, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Solvent-mediated Highly Efficient Synthesis of [1,2,4]triazolo/benzimidazoloquinazolinone Derivatives
Fatemeh Malamiri1, Samad Khaksar2, Rashid Badri3
1Department of Chemistry, Khouzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran.
Objective:
An efficient and catalyst-free procedure for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones has been developed in 2,2,2-trifluoroethanol or deep eutectic solvent(DESs) as a clean reaction media.
Methods:
All of the obtained products are known compounds and identified by IR, 1HNMR,13CNMR, and melting points.
Result:
Various products were obtained in good to excellent yields under reaction conditions.
Conclusion:
We have efficiently developed a practical and catalyst-free approach for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones employing TFE as a clean and reusable media.
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