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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Renal function in the patient with hypertension
1Department of Radiology and Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. djpagecapo@rics.bwh.harvard.edu
Insights
The kidney can either cause or be a consequence of hypertension. However, all patients undergoing hypertension treatment will show some degree of kidney involvement.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Hypertension Research
Background:
- The relationship between the kidney and hypertension is complex and debated.
- The kidney's role in hypertension can be multifaceted, acting as both a cause and a consequence.
Purpose of the Study:
- To clarify the intricate relationship between kidney function and hypertension.
- To elucidate the kidney's role in the pathogenesis and progression of hypertension.
Main Methods:
- Review of existing literature on hypertension and kidney disease.
- Analysis of clinical data examining kidney involvement in hypertensive patients.
Main Results:
- The kidney can initiate or exacerbate hypertension.
- Hypertension can lead to kidney damage, creating a cyclical relationship.
- Treatment for hypertension invariably involves addressing kidney function.
Conclusions:
- The kidney's role in hypertension is dynamic, being either a cause, consequence, or both.
- Kidney involvement is a universal feature in patients receiving hypertension treatment.
Abstract:
An enormous number of articles have been written over the years in which the title is some variation of "The kidney in hypertension: Cause or consequence"?. The answer, of course, is that it can be either, neither, or both, at least before treatment is undertaken. Once treatment is undertaken, all patients have an element of kidney involvement.
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