Related Experiment Videos
Calcium ions: its role in cyanide neurotoxicity
1Department of Physiology, DR.ALM.Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India. mathangidc@hotmail.com
Abstract:
Cyanide is a well-established poison known for its rapid lethal action and toxicity. The central nervous system is one of the main target sites for cyanide toxicity. Cyanide also alters the brain biogenic amine levels. In the present study the role of calcium ions in cyanide toxicity was evaluated using the calcium channel blocker diltaizem (DIL) in Wistar strain albino rats. This study showed that DIL pretreatment prevented cyanide induced changes in the dopaminergic and serotonergic system in the corpus striatum.