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Updated: Aug 4, 2026
09:22
Mouse Pneumonectomy Model of Compensatory Lung Growth
Published on: December 17, 2014
[Pneumonectomy for destroyed lung or chronic tuberculous empyema]
K Inui1, K Reshad, Y Takahashi
1Department of Thoracic Surgery, Kyoto, Japan.
Kekkaku : [Tuberculosis]
|November 1, 1992
Summary
Pneumonectomy is a radical surgery for destroyed lung or tuberculous empyema, offering symptom relief and improved lung function in select patients. Preoperative pulmonary function, specifically %VC and FEV1.0/pr. %VC, are critical indicators for successful outcomes.
Area of Science:
- Thoracic Surgery
- Pulmonary Medicine
- Infectious Diseases
Context:
- Destroyed lung and tuberculous empyema present significant clinical challenges.
- Pneumonectomy is a major surgical intervention for these conditions.
- Limited data exists on the outcomes of pneumonectomy in this specific patient cohort.
Purpose:
- To evaluate the efficacy and safety of pneumonectomy for destroyed lung or tuberculous empyema.
- To identify critical preoperative pulmonary function parameters influencing outcomes.
- To assess the impact of pneumonectomy on patient symptoms and lung function.
Summary:
- Fourteen patients underwent pneumonectomy for destroyed lung or tuberculous empyema.
- Common preoperative symptoms included cough, sputum, and hemoptysis.
- Three patients experienced immediate postoperative complications (hemorrhagic shock, pulmonary embolism, contralateral pneumothorax) managed conservatively.
- The remaining patients showed symptom resolution and improved lung function, particularly those with mediastinal compression from chronic empyema.
- Preoperative pulmonary function thresholds of 40% for vital capacity (%VC) and 25% for forced expiratory volume in 1 second (%FEV1.0/pr. %VC) were identified as critical.
Impact:
- Pneumonectomy can be a successful radical treatment for destroyed lung and chronic tuberculous empyema.
- The procedure can lead to significant symptom reduction and functional improvement.
- Identifying critical preoperative pulmonary function levels aids in patient selection and surgical planning.
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