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Related Experiment Videos

Capsaicin-induced cough in humans.

B Midgren1, L Hansson, J A Karlsson

  • 1Department of Lung Medicine, University Hospital of Lund, Sweden.

The American Review of Respiratory Disease
|August 1, 1992
PubMed
Summary
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Capsaicin effectively induces cough in humans, offering a reproducible and concentration-dependent response. This makes capsaicin a valuable tool for studying cough and evaluating new cough-suppressing medications.

Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Clinical Trials

Background:

  • Cough is a common symptom with various causes.
  • Existing methods for inducing cough in research, like citric acid, have limitations.
  • A need exists for reliable and safe cough-inducing agents for human studies.

Purpose of the Study:

  • To evaluate capsaicin as a selective cough-inducing agent in healthy human subjects.
  • To compare the cough response to capsaicin with that of citric acid.
  • To assess the potential of capsaicin in evaluating antitussive (cough-suppressing) agents.

Main Methods:

  • Healthy subjects inhaled capsaicin aerosol at varying concentrations.
  • Cough response, intensity, and duration were recorded.

Related Experiment Videos

  • Specific airway conductance was measured.
  • Comparisons were made with citric acid challenges.
  • The effect of inhaled lidocaine on capsaicin-induced cough was assessed.

    • Main Results:

    • Capsaicin induced immediate, reproducible, and concentration-dependent cough.
    • Cough subsided promptly upon cessation of capsaicin inhalation.
    • Higher capsaicin concentrations showed a plateau effect on cough.
    • No changes in airway conductance or signs of pharyngitis/laryngitis were observed.
    • Capsaicin-induced cough was inhibited by lidocaine, while citric acid-induced cough was also suppressed by lidocaine.
    • No correlation was found between capsaicin and citric acid cough responses.

    Conclusions:

    • Capsaicin is a selective and effective cough-inducing agent in humans.
    • Its reproducible and dose-dependent nature makes it suitable for cough research.
    • Capsaicin offers potential advantages over citric acid for evaluating antitussive drugs.