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[Multi-resistant strains of Salmonella typhi in Spain]
M A Usera1, A Aladueña, M L Jaime
1Sección de Enterobacterias, Instituto de Salud Carlos III, Majadahonda, Madrid.
Enfermedades Infecciosas Y Microbiologia Clinica
|November 1, 1992
Summary
Most Salmonella typhi strains in Spain remain susceptible to common antibiotics. However, three multiresistant strains carrying a 79 Mdal plasmid were identified, indicating a potential public health concern for antibiotic resistance.
Area of Science:
- Microbiology
- Genetics
- Epidemiology
Context:
- Salmonella typhi is a significant human pathogen.
- Antibiotic resistance in Salmonella typhi poses a global health challenge.
- Surveillance of antimicrobial susceptibility is crucial for effective treatment.
Purpose:
- To report the isolation and characterization of multidrug-resistant Salmonella typhi strains in Spain.
- To identify the genetic basis of multidrug resistance in these strains.
- To assess the prevalence of specific phage types and biotypes among resistant isolates.
Summary:
- Most Salmonella typhi isolates in Spain exhibit susceptibility to standard antibiotics like chloramphenicol, ampicillin, and cotrimoxazole.
- Three distinct multidrug-resistant strains were identified over a two-year period.
- These resistant strains, identified by phage typing and biotyping, harbored a 79 Mdal plasmid conferring resistance and chloramphenicol acetyltransferase production.
Impact:
- Highlights the emergence of multidrug-resistant Salmonella typhi in Spain.
- Identifies a specific plasmid as the likely mechanism for multidrug resistance.
- Informs clinical management and public health strategies for typhoid fever treatment and control.