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Related Experiment Videos

[Protein binding of cephems in the elderly].

M Kuroyama1, S Motohashi, S Murase

  • 1Department of Pharmacy, Kitasato University Hospital.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|November 1, 1992
PubMed
Summary

Elderly individuals exhibit reduced protein binding of cephalosporins, increasing free drug levels. This may lead to enhanced drug effects and adverse reactions in older patients.

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Area of Science:

  • Pharmacology
  • Geriatrics
  • Biochemistry

Context:

  • Serum protein binding influences drug efficacy and safety.
  • Aging can alter physiological parameters affecting drug disposition.
  • Cephalosporins are a class of widely used antibiotics.

Purpose:

  • To investigate the impact of aging on the serum protein binding of 12 cephalosporins.
  • To compare protein binding in young versus elderly healthy subjects.
  • To explore potential reasons for age-related changes in cephalosporin binding.

Summary:

  • Serum protein binding of 12 cephalosporins was evaluated in young and elderly healthy adults using equilibrium dialysis.
  • Elderly subjects showed significantly lower protein binding for these cephalosporins compared to younger subjects.

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  • This reduction is potentially due to decreased serum albumin and altered fatty acid profiles in the elderly, leading to higher free drug concentrations.

    • Impact:

    • The decreased protein binding in elderly individuals may result in increased pharmacological effects and a higher incidence of adverse reactions.
    • Clinical consideration of age-related changes in protein binding is crucial for optimizing cephalosporin therapy in the elderly.
    • Further research into age-specific dosing strategies for cephalosporins is warranted.