Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An evolutionary Wolff's law for trabecular architecture.

S C Cowin1, A M Sadegh, G M Luo

  • 1Department of Mechanical Engineering, City College of The City University of New York, NY 10031.

Journal of Biomechanical Engineering
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physiological and transcriptomic analyses of leaves from Gardenia jasminoides Ellis under waterlogging stress.

Brazilian journal of biology = Revista brasleira de biologia·2022
Same author

[Analysis of the diagnotic results and complications of pneumoconiosis patients with different insurance types].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2020
Same author

[The clinical ananysis of 10 cases of accelerated silicosis].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2017
Same author

Tortuosity and the Averaging of Microvelocity Fields in Poroelasticity.

Journal of applied mechanics·2014
Same author

Dynamic permeability of the lacunar-canalicular system in human cortical bone.

Biomechanics and modeling in mechanobiology·2013
Same author

Analytical basis for the determination of the lacunar-canalicular permeability of bone using cyclic loading.

Biomechanics and modeling in mechanobiology·2011

This study introduces a nonlinear continuum model to predict bone remodeling, accounting for density and architectural changes under stress. The model is essential for understanding trabecular bone adaptation and cannot be linearized.

Area of Science:

  • Biomechanics
  • Materials Science
  • Computational Biology

Background:

  • Trabecular bone architecture adapts to mechanical loads through remodeling.
  • Existing models often simplify the complex, nonlinear relationship between stress, strain, and bone adaptation.
  • Understanding these dynamics is crucial for bone health and implant design.

Purpose of the Study:

  • To develop a nonlinear continuum model for predicting temporal changes in bone density and trabecular architecture.
  • To incorporate experimentally determined remodeling rates and material properties.
  • To investigate the fundamental nonlinearity in bone remodeling.

Main Methods:

  • Formulation of a continuum model based on stress state and bone material parameters.
  • Inclusion of experimentally derived remodeling rate coefficients, stereological, and elastic constant measurements.

Related Experiment Videos

  • Analysis of the nonlinear differential equations governing architectural evolution.

    • Main Results:

    • The model demonstrates that bone remodeling dynamics are inherently nonlinear.
    • Nonlinearity arises from the changing stress-strain relationship during remodeling.
    • A linearized model would eliminate the feedback mechanism for architectural adaptation.

    Conclusions:

    • The proposed nonlinear continuum model accurately captures the temporal evolution of trabecular bone architecture.
    • The model highlights the necessity of nonlinear terms for simulating adaptive bone remodeling.
    • Limitations include applicability at larger length scales and homogeneous bone regions.