[Degradation of endo- and exogenous albumin in normal and starved rats]

A rate of degradation of homologous exogenous 14C-albumin proved to be higher 3-fold as compared with that of endogenous 14C-albumin, while the albuminolysis rate was additionally increased in starvation. Evaluation of 14C- and 3H-labels demonstrated that the protein hydrolysis occurred mainly in liver tissue, kidney and intestinal membrane and its rate was elevated in starvation. Dissimilar secretion of exo- and endogenous albumins into small intestine lumen was detected. Removal of albumins was found to depend on augmentation in the proteolytic potential and on reconstructive activity of secondary lysosomes.