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Updated: Jul 24, 2026
08:05
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
[Complement system in status asthmatics--analysis of anti-complementary effects induced by methylprendisolone]
H Onodera1, S Takemura, Y Kasamatsu
1First Department of Internal Medicine, Kyoto Prefectural University of Medicine.
Arerugi = [Allergy]
|November 1, 1992
Summary
Methylprednisolone (MPS) treatment in status asthmaticus modulates the complement system, normalizing certain activities and reducing complement activation. These anti-complementary effects are linked to improved asthma symptoms.
Area of Science:
- Immunology
- Pharmacology
- Respiratory Medicine
Context:
- Status asthmaticus involves complex immune dysregulation.
- The complement system plays a role in inflammatory airway diseases like asthma.
Purpose:
- To investigate the effects of methylprednisolone (MPS) on the complement system in patients with status asthmaticus.
- To explore the relationship between complement activation and asthmatic symptoms.
Summary:
- Methylprednisolone (MPS) treatment in status asthmaticus patients modulated complement hemolytic activities and protein profiles.
- MPS demonstrated direct inhibitory effects on complement components C1s and D in vitro.
- The study suggests that MPS-induced anti-complementary effects may contribute to improved asthma control.
Impact:
- Provides insights into the immunomodulatory mechanisms of methylprednisolone in severe asthma.
- Highlights the potential role of the complement system in the pathophysiology of status asthmaticus.
- Suggests that targeting the complement system could be a therapeutic strategy for severe asthma.
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