Practical use of retinoids in psoriasis

Area of Science:

• Dermatology
• Pharmacology

Background:

• Retinoids have significantly advanced dermatologic treatments over the past two decades.
• Isotretinoin and etretinate have shown dramatic efficacy in severe acne and pustular psoriasis, respectively.

Purpose of the Study:

• To review the utility, safety, and cost-effectiveness of retinoids in dermatologic practice.
• To highlight the benefits of retinoids, including combination therapies, for recalcitrant skin conditions.

Main Methods:

• Review of clinical outcomes with retinoid therapy, including isotretinoin and etretinate.
• Evaluation of combination therapy with UV light (retinoid-light combinations).
• Consideration of retinoid safety profiles, particularly regarding pregnancy prevention.

Main Results:

• Retinoids offer effective treatment for severe acne and pustular psoriasis.
• Combination therapy allows for reduced retinoid and UV light dosage with improved response.
• Retinoids are generally safe and cost-effective therapeutic options.

Conclusions:

• Retinoids are a powerful therapeutic option for severe and recalcitrant dermatologic conditions.
• Careful patient management, especially concerning pregnancy prevention, is crucial for safe retinoid use.
• Ongoing molecular biology research suggests a promising future for retinoid-based therapies in dermatology.