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[Atherosclerosis: the risk factors]
M Buschini1, M Zanetta, M Bielli
1Divisione di Medicina, Ospedale di Borgomanero, NO.
Insights
This study highlights that traditional risk factors and metabolic control are crucial for managing vascular disorders in non-insulin-dependent diabetics. Elevated fibrinogen is linked to vascular issues, particularly in non-diabetics.
Area of Science:
- Cardiology
- Endocrinology
- Metabolic Syndrome
Background:
- Vascular disorders are a significant complication in non-insulin-dependent diabetes mellitus.
- Identifying reliable markers for vascular complications is essential for patient management.
Purpose of the Study:
- To investigate the relationship between traditional risk factors, specific laboratory values, and the presence of vascular disorders in non-insulin-dependent diabetics.
- To evaluate potential biomarkers for vascular complications in this patient group.
Main Methods:
- A cohort of 196 outpatients, including 112 non-insulin-dependent diabetics, were categorized into subgroups based on vascular disorder status.
- Statistical analyses, including correlation coefficients and chi-square tests, were performed on risk factors (smoking, family history, hypertension, BMI) and laboratory values (cholesterol, triglycerides, fibrinogen, HbA1c, factor VIII, PF4, BTG).
Main Results:
- Traditional risk factors and good metabolic control (HbA1c) are confirmed as important for diabetic patients.
- PF4, BTG, and factor VII did not show utility as markers for vascular disorders in this study.
- An increased fibrinogen level was observed in individuals with vascular disorders, especially in non-diabetic subjects.
- A correlation between certain factors and serum triglycerides was noted, particularly in diabetic patients with vascular disorders.
Conclusions:
- Metabolic balance and established risk factors remain paramount in managing non-insulin-dependent diabetes and preventing vascular complications.
- Fibrinogen may serve as a potential indicator for vascular disorders, particularly in non-diabetic individuals.
- Further research is needed to validate PF4, BTG, and factor VII as biomarkers in this context.
Abstract:
A group of 196 outpatients among whom 112 non-insulin-dependent diabetics were divided into 4 subgroups according to whether they had vascular disorders or not. For statistical evaluation by means of correlation coefficient and chi-square test both risk factors (smoking, family history, arterial hypertension, BMI) and laboratory values (total and HDL cholesterol, triglycerides, fibrinogen, HbA1c, factor VIII, PF4, BTG) were taken into account. Our findings confirm the relevance of risk factors and the need for diabetic patients to be metabolically well balanced; PF4, BTG, and factor VII were normal in all patients which suggests that these are not suitable, as far as the present study is concerned, to be considered markers of vascular disorders. An interesting correlation was found between these factors and serum triglycerides, especially in the subgroup of diabetics with vascular disorders. An interesting finding was the increase of fibrinogen in subjects with vascular disorders especially in non-diabetics.