[Liver metabolism during massive hemorrhage and subsequent blood transfusion]

Content of lactate, pyruvate as well as activity of hexokinase, phosphorylases, ATPase and transaminases were studied in dog and rat liver tissues under conditions of acute profuse hemorrhage and after its complete compensation by autogenic, isogenic blood and by sodium chloride 0.9% solution. Distinct inhibition of the hexokinase activity in the hemorrhage led to impairment of glucose utilization in liver tissue and to development of hyperglycemia. Alterations in arterial blood pressure correlated with the activity of tissue enzymes. Tissue metabolism was improved after compensation of blood losses by adequate amounts of blood at early period of hemorrhagic shock.