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Lack of toxicity of intravitreally administered interferon alpha-2a
M A Karaçorlu1, G A Peyman, S Cruz
1School of Medicine, LSU Eye Center, New Orleans 70112.
Ophthalmic Surgery
|December 1, 1992
Abstract:
We investigated the toxicity of single doses of intravitreally administered interferon alpha-2a in albino rabbits. Following injection of interferon in doses of 40,000, 80,000, 160,000, 320,000, and 640,000 IU/0.1 mL, no significant histologic changes were detected by light and electron microscopy. Photopic and scotopic electroretinography showed no alteration of retinal function.