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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Dynamic determinants of left ventricular early diastolic filling in old myocardial infarction

K Katayama1, M Matsuzaki, K Moritani

  • 1Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Japan.

Japanese Circulation Journal
|July 1, 1992
PubMed

Insights

Angiotensin infusion impaired early diastolic filling in patients with myocardial infarction by reducing mitral inflow velocity and time-velocity integral. This occurred despite unchanged atrial-ventricular pressure gradients, highlighting altered diastolic mechanics.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Medical Research

Background:

  • Left ventricular early diastolic filling is crucial for cardiac function.
  • Myocardial infarction can significantly alter diastolic properties.
  • Understanding diastolic dysfunction is key to managing heart failure.

Purpose of the Study:

  • To assess the determinants of left ventricular early diastolic filling.
  • To investigate the effects of angiotensin infusion on diastolic function in patients with old myocardial infarction.

Main Methods:

  • Simultaneous measurement of left atrial pressure (LAP) and left ventricular pressure (LVP) using micromanometry.
  • Pulsed Doppler mitral inflow velocity assessment.
  • Angiotensin II infusion (20 ng/kg/min) and thermodilution cardiac output measurement.

Main Results:

  • Angiotensin infusion increased LV peak systolic and end-diastolic pressures but decreased cardiac index.
  • The pressure gradient interval significantly decreased, indicating altered diastolic timing.
  • Peak early diastolic mitral inflow velocity (peak E) and its time-velocity integral (Ei) were significantly reduced.

Conclusions:

  • Angiotensin infusion impairs early diastolic filling in patients with myocardial infarction.
  • Reduced diastolic filling is associated with decreased mitral inflow velocity and altered pressure gradient dynamics.
  • These findings suggest impaired relaxation or increased diastolic stiffness post-myocardial infarction.

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