Related Experiment Videos
Etoposide microcrystals suspended in oil: a new dosage form to peritoneal carcinomatosis in mice
A Hagiwara1, T Takahashi, T Sasabe
1First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Oncology
|January 1, 1992
Abstract:
Etoposide microcrystals suspended in oil (ETOP-OIL) were examined for their therapeutic effects on peritoneal carcinomatosis in mice. Two days after intraperitoneal inoculation with 10(5) P388 leukemia cells/mouse to CDF1 male mice, etoposide at 10-80 mg/kg was administered intraperitoneally in bolus in the form of ETOP-OIL or in the aqueous solution form. In every dose, the survival curve of the mice given ETOP-OIL was statistically significantly improved in spite of its small lethal toxicity, as compared with those given the identical dose of etoposide aqueous solution.