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NMR spectroscopic and magnetoencephalographic studies in migraine with aura: support for the spreading depression
K M Welch1, G L Barkley, N M Ramadan
1William T. Gossett Chairs Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.
Pathologie-Biologie
|April 1, 1992
Abstract:
The authors propose that patients who suffer from migraine with aura have a susceptibility to spontaneous neuronal discharges and subsequent spreading depression. This is based upon a state of central neuronal excitability involving the excitatory neurotransmitter glutamate, in combination with supersensitivity of the N-méthyl-D-aspartate (NMDA) receptor. This hypersusceptibility is supported by increased turnover of high-energy phosphates, low intracellular Mg2+ and large amplitude depolarizing waves on magnetoencephalography (MEG).