Related Experiment Videos
CA 19-9 expression in subacute (de Quervain's) thyroiditis: an immunohistochemical study.
K W Schmid1, C Ofner, T Ramsauer
1Department of Pathology, University of Münster, FRG.
Summary
Carcinoma antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA) can help identify subacute granulomatous thyroiditis. These markers show distinct expression patterns in various thyroid conditions, aiding in histomorphological definition.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Subacute granulomatous thyroiditis (SGT) diagnosis can be challenging.
- Immunohistochemical markers like CA 19-9 and CEA may aid in differentiating thyroid conditions.
Purpose of the Study:
- To investigate the expression of CA 19-9 and CEA in SGT and other thyroid pathologies.
- To assess the utility of these markers in the histomorphological definition of SGT.
Main Methods:
- Immunohistochemical analysis of CA 19-9 and CEA expression.
- Study included 48 cases of SGT and various other thyroid conditions (lymphocytic thyroiditis, Hashimoto's, Graves', follicular adenomas/carcinomas, papillary carcinomas).
Main Results:
- CA 19-9 was expressed in all SGT, lymphocytic thyroiditis, and papillary carcinomas, and in ~50% of follicular adenomas/carcinomas.
- Strongest CA 19-9 staining observed in late-stage SGT and sclerotic papillary carcinomas.
- CEA was present in acute SGT granulomas but negative in all neoplasms; both markers occasionally found in multinucleated giant cells of SGT.
Conclusions:
- CA 19-9 and CEA expression patterns can assist in the histomorphological diagnosis of subacute granulomatous thyroiditis.
- The presence of these markers in multinucleated giant cells suggests a histiocytic or follicular cell origin.